![]() The cost of the drug has risen over the years, leading to Menendez's attack. Menendez's criticism centers on Hugin's nearly two-decade career as head of Celgene, which markets a cancer drug called Revlimid that has proved a market and medical success. "I think people are going to look at the totality of my decisions and my actions versus Bob Hugin's decisions and actions, and I think that I'm happy to let the fate of the election rest on that." "I don't think New Jerseyans are going to buy the judgment of Bob Hugin, who ultimately made a killing off the back of cancer patients," Menendez said. While pivoting to attack Hugin, he also said he thinks voters will consider his entire career. Menendez, during an interview in Union City, pointed out that the jury didn't "believe the government's case on any given count." Asked whether voters might question his judgment, he listed Senate accomplishments including getting federal aid after Superstorm Sandy and helping draft the Affordable Care Act. "This election is about New Jersey, and it's Bob Hugin versus Bob Menendez, corrupt and ineffective, versus someone who has had a life of service and committed to outcomes and improving the quality of life of all New Jerseyans," Hugin said. Hugin said in an interview he would not have entered the race had it not been for Menendez's corruption trial. He was also admonished by the Senate Ethics Committee over it in a strongly worded letter, though the full Senate stopped short of a censure vote. Salomon Melgen in return for help settling a Medicaid billing dispute. ![]() Menendez was indicted on charges he accepted lavish gifts from longtime friend Dr. One Hugin ad says Menendez thinks voters are stupid because he "thinks he can get away with corruption," a reference to a federal corruption trial that ended in a mistrial before prosecutors dropped the charges in January. The attacks have been sharp and personal, and New Jersey residents have seen them on television and online for months, with the prospect for months more of negative ads. That's a tighter gap than a March survey that showed Menendez with a 13-point lead. The poll surveyed 908 registered voters and had a margin of error of plus or minus 4.6 percentage points. A Quinnipiac University poll out last week showed Menendez with a six-point edge over Hugin, 43 percent to 37 percent. ![]()
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![]() ![]() If you download your font from the web, the licensing information is usually included as a text file.Īdobe Illustrator is a vector-based program, which means it is better suited to export PDFs. Pro tip: A font can only be embedded if it is permitted by the font vendor. Keep in mind that this will increase the size of your file, but will ensure your fonts are correctly displayed. The font will be locally available on the device’s computer while the file is opened. This means it is easily referenced across devices, even if a particular device does not have the fonts installed. What does embedding fonts do?Įmbedding fonts into your document ensures that all of the font information used in the file is stored in it. This could result in your design looking quite different than you intended. If the devices do not have the same fonts, they will automatically substitute your fonts with what they have on hand. Well here’s why it will ensure your design displays as you intended across devices and in print regardless if the device displaying your file, or the printer, has the same fonts you used. ![]() You may be wondering why it is so important to embed your fonts. It is always a good idea to embed your fonts into your file, especially if you intend on printing your design. Even if you are using a font that came preloaded on your device, it is possible your printer may not have the same one installed. Professional printing companies have a collection of different fonts, but if you are using a special font, it is likely they will not have it. Some come preloaded on your device or with your software, and some can be downloaded from various websites on the internet. If you are involved in the world of design, you are likely aware that there are many fonts to choose from. ![]() ![]()
![]() iPSC colony numbers are from three biological replicates. ∗∗p<0.01 compared with mutant OCT4 #p<0.01, #p<0.001compared with hnRNPA- or FUS-IDR. Mutations of OCT4 reduce the reprogramming efficiency, which is restored by IDR fusion. (D) CFA is performed to compare the influence of WT, mutant and IDR-fused OCT4 on reprogramming efficiency. 20uM proteins were added into droplet formation buffer with 125 mM NaCl and 10% PEG8000. (A–C) Representative images of droplet formation showing that OCT4 can form droplets in vitro with MED1-IDR. Phase separation regulates cell fate transitions These results support that our approach can effectively control phase-separated capacity of proteins. Furthermore, the disabled phase separation ability of OCT4 mutants can be rescued by fusing an IDR of FUS or hnRNPA ( Wang et al., 2021). Both acidic mutation and residue deletion can disrupt OCT4 condensates in vivo and OCT4 droplets in vitro, demonstrating IDR perturbations can destroy the phase separation capacity of proteins. These claims are also validated by in vivo study showing that OCT4 can form phase-separated condensates in vivo, which can fast recover after photobleaching ( Wang et al., 2021). OCT4 droplets can fuse, and can fast recover after photobleaching, indicating OCT4 droplets have liquid-like behavior. These results demonstrate that OCT4 phase separation needs the participation of coactivator such as MED1. The IDR of MED1 is required for OCT4 to form circle-like droplets ( Figures 4B and 4C). OCT4 alone can form irregular aggregates ( Figure 4A), which is not associated with phase separation. GelCode TM Blue Safe Protein Stain Buffer ![]() Chemicals, peptides, and recombinant proteins ![]() ![]() Next the artifact needs linking to the pipeline. Now press the X in the right to close this blade. This is directly linked to naming of your web.config transforms.įor example, a stage name of Release would mean that during the deployment process it would use the transformation file.įor the purposes of this walk through I have entered Release. In the Stage name text box input your build environment type. Beneath that will be a button called New pipeline click this to begin the process. Once there you will be presented with a message saying No release pipelines found. Creating the Release Pipelineįirst browse to the Releases menu item under the Pipelines menu. ![]() That is the build process done with, next up is configuring the release pipeline. Search for this in the same way as the Archive task, instead entering publish build artifacts in the search box and adding the first result to the stage.Ĭonfigure this task by setting Path to publish as follows: $(Build.ArtifactStagingDirectory)/ Next you will need to add the publish task. Select zip from the Archive type dropdown, and then finally enter the archive name in to the box titled Archive file to create, for example: $(Build.ArtifactStagingDirectory)/ Root folder or file to archive: $(Build.ArtifactStagingDirectory)/$(Build.BuildId) To do this click the plus on the Agent job 1 bar then in the blade enter the following into the search box in the top right "archive files", adding the first result with the same name to the stage. You will then need to add the Archive task. p:AutoParameterizationWebConfigConnectionStrings=False p:DeleteExistingFiles=True /p:publishUrl="$(Build.ArtifactStagingDirectory)\$(Build.BuildId)" At this point you will want use the MSBuild arguments defined below: /p:DeployOnBuild=True /p:DeployDefaultTarget=WebPublish /p:WebPublishMethod=FileSystem The build process requires a few changes to work with the FTP release pipeline, so you can follow part two up until the Adding the build tasks section. I will be deploying the same application I built in part two of the original series to a Standard Package on UmbHost, firstly using FTP and then using Web Deploy. In this bonus article I will show how to use Azure DevOps to deploy to an FTP(S) server or Web Deploy in cases where you may not have the Azure agent available. ![]() ![]() ![]() Download Now Learn how ComboCleaner works. ![]() This way, you may reduce the cleanup time from hours to minutes. Therefore, it is recommended to download Combo Cleaner and scan your system for these stubborn files. At that point, the popup saying “I cause problems on purpose”, which is often triggered by the goose, assumes some unnerving implications and the user will probably start thinking it’s not that funny anymore.ĭesktop Goose may re-infect your Mac multiple times unless you delete all of its fragments, including hidden ones. If there is some unsaved work, it will be lost. As a result, the multitude of these entities gets too resource-intensive for the hardware to handle and the computer may crash in the long run. It may seem that some clicking to close these notes will get them out of sight, but this is a no-go if the goose has pilfered the cursor, which it tends to do off and on. It goes without saying that the effect is going to be much worse if the machine is left unattended for a longer period of time. If the user happens to be away from their Mac for half an hour or so, they will discover a disorderly cascade of windows with memes being opened all over the desktop. Officially distributed via the /desktop-goose web page, the Desktop Goose game ends up being a mixed blessing when inside a computer. Underneath this prettiness lurks a memory hog that can make a Mac act up badly. Sounds like a ton of fun, doesn’t it? However, the margin between fun and trouble can be a slim one. ![]() Furthermore, the pixels are deliberately made discernible in the feathered character’s on-screen manifestation to add some extra delight to the whole impression. It honks all the time, steals the mouse cursor, smears the screen with muddy tracks, and leaves notes with various memes in them. The pivot of the game, though, is a cartoonish goose that plays a central role by messing around with the user’s desktop and all the open applications. This app has recently exploded into the wild due to its somewhat silly nature combined with a bunch of prank effects that can make the grimmest person smile. The fans of procrastination will definitely find the new Desktop Goose game entertaining, plus a good deal of time-conscious computer users don’t mind following suit to have a laugh once in a while. Running a hilariously simple game called Desktop Goose is an amusing thing, but Mac users who care about system performance would be better off removing it. ![]() ![]() ![]() If you’ve forgotten or if someone else set it up for you, then check out our guide on how to find your WiFi password. Assuming you set it up yourself, you should remember it. It allows you to create private QR codes so that only you can see your information. Password – This is the password that you’ve chosen to connect to your WiFi network. Online QR Code Generator provides a free online QR code generator service, can generate corresponding QR code images from an electronic business card, text. Use BlockSurveys free privacy-focused QR code generator. However, if you’re unsure, in Windows 10, open your WiFi settings, click on Properties under the current network you’re connected to, and look for Security Type. For the most part, most routers use the WPA/WPA2 encryption by default. If you setup your router yourself, then the name should already be familiar to you.Įncryption type – There are several different encryption types that are available when setting up your WiFi, depending on your router. Simply open your phone’s WiFi settings or computer WiFi settings and you should see the name that your device is connected to. SSID – This is basically the name that you’ve chosen for your home’s WiFi network. You will also have the option of exporting the QR code or printing it to paste it on your wallįor those who aren’t familiar with their WiFi SSID or encryption type, here’s what you need to know:.Click the “Generate!” button to create the QR code.Enter your home’s WiFi details like SSID, encryption type, and password. ![]() Does this sound like something you could see yourself using in the future? If it does, then here’s what you need to do to create a QR code for your WiFi. This project, qrpwd, was inspired by the need for a secure and convenient way to store 2-factor authentication (2FA) backup codes. You can even create a printout and paste it on your wall or fridge so that they can scan it themselves when they want. There are many free online QR code generators available, but Flowcode is the most powerful platform. Online QR Code® Generator Create Free QR Codes Immediately Use the created QR codes to visit web-pages, dial phone numbers, text messages, send tweets, share contact data, access Wi-Fi networks, etc. ![]() By creating a QR code, guests to your home can use their smartphones and quickly scan the code and connect to your WiFi, saving you the time and trouble of having to give it out manually. Thankfully, there is a quicker way of giving your guests access to your home’s WiFi and that is by generating a QR code. Maybe you use this password for other things and you’d rather not give it outright, or maybe you’re tired of having to repeat it over and over again. We’re sure that many of us have had that experience when your friends or family members come to your home and ask for the WiFi password. ![]() ![]() ![]() Memorandum, Taquey to Johnson re: influencing foreign response to Rosenberg case, Telegram, Ambassador Douglas Dillon to President regarding foreign response to Rosenberg case (and reply), įlyer, clemency rally announcement (includes Michael Rosenberg's letter to President Eisenhower), no date Memorandum, Korns to Craig regarding communism and Rosenberg case, Ma Memoranda for file regarding Michael Rosenberg's note to President Eisenhower, Febru Memo of telephone conversation between Secretary of State John Foster Dulles and Press Secretary James Hagerty regarding story of Pope's intervention, Febru Memoranda, Hopkins to Stephens re: public response to President's action in Rosenberg case, Febru Minutes of Cabinet Meeting, President Eisenhower's view of case, Febru(page 3 only) Letter, Tom Stephens to Attorney General Herbert Brownell and Draft Presidential Statement by the Psychological Strategy Board, Janu Memorandum, Kirk to Smith re: foreign response to Rosenberg case, Janu Memorandum, Edward O'Connor to Admiral Kirk, regarding possibility of Rosenberg case carrying over into Eisenhower Administration, JanuĪpplication for Executive Clemency, denied by President Eisenhower, Janu Eisenhower declined stating: "The nature of the crime for which they have been found guilty and sentenced far exceeds that of the taking of the life of another citizen it involves the deliberate betrayal of the entire nation and could very well result in the death of many, many thousands of innocent citizens…" One of the first decisions facing newly elected President Eisenhower was whether to grant executive clemency to the Rosenbergs. Their guilt has been confirmed by Soviet documents made available after the fall of communism. Their case remains a cause celebre today, with claims it was the result of Cold War hysteria. Members of the communist party, the Rosenbergs were convicted of passing secret information about the atomic bomb to the Soviet Union in 1945. In June 1953, Julius and Ethel Rosenberg were executed for conspiracy to commit espionage under the U.S. ![]() ![]() I understand that people want to make money from the music industry, but some people in the music business or industry are driven solely by making money or profit and they don’t even like music. There are too many people involved in the music industry for the wrong reasons. What do you think could be done to improve the industry in the future? The music industry took a massive hit during lockdown. I added seven well-known rebel songs too like Sean South and Celtic Symphony too He has so many great ideas for my songs, can add so many instruments and can play them all himself. Sticks is such a brilliant musician and adds so much to a song. It was recorded in Strabane, Tyrone, with a good friend of mine, Sticks Doherty. I wrote three songs on the album- Rebel Soul, We Hail To Celtic and Our Island. I loved making the album Rebel Blood, Fenian Heart. You recently wrote and recorded a brilliant album called Rebel Blood, Fenian Heart how did you find the process? I suppose if I can try to categorise or describe the style of music I play, it would be rock, rebel and country. What style of music would you say you play and why did you choose that style? The words just resonate as you sing it, you imagine yourself as the protagonist in the song. It was always one of my favourite songs growing up and I’ve been told by a few people that my version of the song is not too bad. I’ve been to Glasgow loads of times, but never to play a gig, so that is something I would love to do.ĭo you have a favourite song to perform and why?Ī Sniper’s Promise. I’ve never played in Glasgow, but if I did it would probably have to be Grace’s Bar. You feed off their enthusiasm and the more crowd enjoy the gig, the more you want to playįollowing on from that, are there any venues you’d love to play? There are so many brilliant venues and great crowds in Ireland. You play a wide variety of venues in and around Dublin. His anger, his lyrics, his rage, his guitar playing, his persona… He is, without a doubt, a legend! Egos can be a massive put off with band’s which I try to avoid. You rely on each other on stage, you read each other’s playing style and work in harmony together. But I really do appreciate bands because it’s such hard work. Have you always played solo or have you played as part of a band? If so which do you prefer?ĭefinitely solo. ![]() I enjoy the storytelling in a song-songs that convey a message. Songwriting is just something you develop over time. How did you learn to write your own material?īy listening to bands and musicians that I loved growing up. For me, songwriting is just figuring things out in your mind, writing your thoughts on paper and moulding it piece-by-piece into a song. It can’t be narrowed down to one person or one songwriter. Who inspired you to write and perform the songs you do? The guitar was never encouraged, which is why, I suppose, I kept learning and playing more and more. They were more Gaelic football and soccer orientated. Were your family musical? And if so did they encourage you to pick up the guitar? As I got into my teenage years, it was all Oasis, Nirvana, REM and so on, so I still love rock music too. I grew up listening to Irish Rebel music which I still love to this day. Let’s find out a bit more about him.Īt what age did you gain an interest in music and why?įrom a very young age. Kev (above) burst onto the livestream scene at the beginning of lockdown and has been a regular ever since, gathering a world wide audience. ![]() GLASGOW Irish Bands and Gigs this month takes a trip over to Dublin to catch up with the talented Kevin O’Driscoll. ![]() ![]() ![]() If you are having trouble getting clean lines when cutting out dough or the dough is just too difficult to handle, roll it out, and then chill the dough in the refrigerator or freezer. For stiffer doughs, just pass over the dough more times with the rolling pin rather than muscling through it by pressing too hard.įifth, chill it. It's thinner and more flexible than the bleached kind, and allows you to follow Secret Number 2 above like nobody's business.įourth, take it easy! If you press too hard during rolling, you'll get those unsightly creases when you're rolling between two sheets of that unbleached parchment. Third, use unbleached parchment paper when rolling between two sheets of paper. Trust those hands! They're a cook's best tools. Running your hands lightly across the dough will tell you everything you need to know about where to roll thinner, where to leave the dough be. Your hands are much more sensitive in this regard than your eyes, because your eyes simply can't compare the relative thickness of the dough from one spot to another. Rolling out the dough into an even layer is the most challenging and scariest part of the whole process. Others, between two sheets of unbleached parchment paper. Some doughs should be rolled out on a lightly floured surface, sprinkling lightly with more flour as you roll out the dough (like this one). So (forgive me), let's get rolling!įirst, follow the rolling instructions in the recipe. But in case you don't have the book yet, or you just haven't read it like a novel (you mean not everyone does that with cookbooks? ), I'm giving you the abbreviated version of those secrets here today on the blog. On page 28 of my newest cookbook, Gluten Free Classic Snacks, I spill all those secrets in detail. If you see a recipe that calls for rolling out dough and click away or turn the page, we need to talk! Rolling out out anything, be it cookie dough, cracker dough, pie crust or even pizza dough, is really very simple once you know the secrets. Today's recipe for Gluten Free “Chicken-In-a-Biskit” Crackers, a copycat of the crispy, buttery and flavorful Nabisco favorite, is because most cracker manufacturers are just not going to bother putting out a gluten free version-and because so much of what you can buy is still just too expensive! About rolling out dough It forces prices down and quality up, and some of the gluten free crackers you can buy are really lovely (I'm looking at you, Nut Thins!). And that's great! I love it when new gluten free products enter the marketplace. These days there are more and more packaged gluten free crackers being sold in regular grocery stores. ![]() |